3. COVID-19 Prevalence and Incidence

(3/17/20) Based on the analyses described in my previous post (below) and updated to today’s latest World Health Organization (WHO) data, I can make the following estimations for three time points, 3 weeks ago, today and 3 weeks from now:

You’ll need to bear with me as I explain this.

  • Recall that I am taking cumulative and weekly rates of death to surmise the prevalence (total cases) and incidence (new cases/week) for 3 weeks ago (2/23/20). That is because I assume that anyone who dies, contracted the illness on average 3 weeks earlier.
  • So on 2/23/20, I predict that there were 8,500 people in the US with COVID-19 (assuming a 1% mortality rate). Reports would have said less than 1,000, but plenty are missed for lack of testing.
  • I then calculate the prevalence and incidence by fitting a polynomial function (n=2-4 to get a good fit) the growth rate for death (see plots below or take my word for it). The polynomial fits to the curves have uncertainty so I provide low and high estimates. The plots and functional fits (for the high estimate cases) are shown below and complement the plots I emailed on 3/14 (further below).
  • So today I predict that there are 48,000 – 130,000 cases of COVID-19 in the US. The documented number is several thousand, but again a gross under-counting, so I totally ignore those pronouncements and why I started my own modeling.
  • So the US is at a very low prevalence relative to the population of 350,000,000, however, the growth rate is quite high and accelerating, so we need to exercise social distancing.
  • I also predict total deaths (low and high estimates) for the US, WW and other countries for 3 weeks from now based on the polynomial fits.
  • China and S. Korea, if the WHO database is to be believed, have done a remarkable job of containing COVID-19.
  • Italy is by far the most scariest scenario. The death rate is accelerating, but that reflects an acceleration of the prevalence about 3 weeks ago, so we will not know how effective the aggressive government intervention is until we see a rolling off of the death rate, which as I said is about a 3 week lagging indicator.
  • Same goes for the U.S. The death rate is growing at about the same rate as Italy (75% of the total deaths in just the last week). However, that is working from low numbers in the US. High estimates for prevalence of COVID-19 are about 1/3000 for Americans, but for Italians an alarming 1/30. So we are in better shape by a factor of about100x.
  • Now there are a lot of assumptions in my model, e.g., I am not accounting for recovery, but if the growth rates are accelerating that will not take things down much.

The reason I did this modeling is because of all the suspect reporting out there about total confirmed cases, which are meaningless because of gross under-counting. Further the growth rates are more due to increased testing than to actual incidence. Further I have seen some doomsday claims of hundreds of thousands of infections in the US based on nothing but conjecture. Finally the “professional” epidemiologists and modelers are getting way to complicated using to many ill-defined variables. In fact the only statistic that matters is death. That’s usually an accurate number.

I will be following the death trends and hope we see a rolling off in the US and elsewhere in the world. If Italy gets a grip on their problem, then we can be assured that the rest of the world will be OK. Hard to say what would be considered sufficient tapering off to relax social restrictions. But if China and S. Korea are any indications it could be as soon as, but not less than, 1 month. Still I’m cautiously optimistic about the prospects for the U.S. and WW.

2. Death Statistics and Trends

(3/15/20) As I’ve expressed before, I’m not satisfied with the reporting of COVID-19. Not surprising, but also appalled at the so-called experts who either like to pontificate or like to shock the public into dooms day scenarios without doing the calculations.

I tapped into the WHO (World Health Organization) data base and downloaded some key data on excel files (I will be updating these daily). Below are plots of death rates cumulatively (linear and log) and per day (linear and log). In my previous post (below) I stated that this is the only hard data we have and a potentially important way to assess trends. If we assume this is representative of incidence upon infection (at least two weeks earlier), we can use this as a prevalence (cumulative) and incidence (daily) indicator that we can then extrapolate later (by about 2-3 weeks) to get the present-day infection numbers. Here is how I worked it up and my commentary:

  • China: If we can believe the numbers, they have radically controlled the number of outbreaks and deaths. I thought there might be state deception so I was looking for dislocations in the data that did not fit any reasonable (if not normal) distribution as a red flag to fudging the numbers; but not actually seeing that. Seems believable at this point.
  • U.S. is not in big trouble, yet. These are high growth rates, but working off of very low numbers. However, there is a definite acceleration. Will follow carefully over next few weeks.
  • WW is not super alarming but maybe pulled down by China recovery statistics.
  • Italy – This country has a huge problem. An accelerating epidemic and a case study how this could escalate to any other country. Important to find out how this got so out of hand before government intervention came into play.
  • South Korea is getting a handle on things. It is at less than 10% of Italy now and receding faster. Another example of government intervention working.

One of the conclusions for the U.S. is that the number of real infections (much greater than those confirmed by tests) is not 100x as some pundits say, but maybe 10x. How do we know? By determining the death rate for today, representing incidence two weeks ago and then extrapolating to today. Quick calculation is if 6 deaths a day today represents incidence about 3 weeks ago and if giving an upward estimate of 15 deaths/days over the next 3 weeks and a mortality rate of 1% says 420 deaths over the next 3 weeks and therefore today there must be 42,000 with COVID-19. My gut says must be more, but the numbers based on deaths seem less alarming then we are reading in the press, at least in the U.S. If it is truly more then it suggests the mortality rate may be less than 1%. So, it doesn’t matter. What really matters is the death rate and when does that start to roll over. Need at least 2 more weeks of data to get good trends.

1. COVID-19 Testing in the U.S.

(3/14/20)

The Table above shows how poorly we are doing implementing COVID-19 tests in the U.S. vs. other countries. So in the U.S. today we have about 3,000 confirmed cases and 57 deaths. The former is a leading indicator and the latter a lagging indicator, which is why you can’t divide them to get a mortality rate. All the confirmed US cases are by tests. You can see tests are administered to only 0.0005% of the U.S. population. So how to calculate the true prevalence? Generally by using the death rate and dividing by the presumed mortality rate. In that case it doesn’t look so bad if we only have 57 deaths. That would say about 5,700 cases (assuming a 1% mortality rate). But some people estimate that real cases in the US are 10-100x confirmed cases and I can’t disagree. If so there should be a lot more deaths coming up. The best metric will be death growth rate. Today there were 8 more deaths in the U.S, which would say about 800 new cases per day 2-3 weeks ago assuming death comes 2-3 weeks after infection. If I track this for a few days I can get the growth rate, which would give prevalence and incidence for 2-3 weeks ago. I can then extrapolate prevalence today based on the trend. I’m sure someone else is doing this but I can’t find anything.